About 9 percent required dose reductions. CT completion rates were high in both PCb and CEF-T arms (95 percent and 93 percent, respectively). Platinum-based regimen] is superior to the anthracycline/taxane regimen for early-stage TNBC,” they said.Ī total of 647 women (mean age 51 years) with early-stage TNBC (74 percent node-negative ) were randomized to receive either PCb** or CEF-T***. Or the first time, to our knowledge, [our findings showed that the “ to determine whether PCb is superior to CEF-T in the adjuvant setting of TNBC … However, there is insufficient evidence for platinum-based therapy in the adjuvant setting, they pointed out. Variant carriers ,” said the researchers. “latinum-containing regimens have been proven to be effective in gBRCA1/2
Keymo alternative trial#
A paclitaxel-carboplatin (PCb) regimen may be an alternative adjuvant chemotherapeutic strategy for women with operable triple-negative breast cancer (TNBC), given its greater benefit over a conventional regimen comprisingĬyclophosphamide, epirubicin, and fluorouracil, followed by docetaxel (CEF-T), the phase III PATTERN* trial has shown.Ĭompared with other BC subtypes, TNBC is more likely to have a higher histologic grade and be more aggressive, thus increasing the risk of local recurrence and visceral metastasis.
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